Possible Covid19 Protection

[CJJon]

Why some people who haven't had Covid-19 might already have some immunity - CNN

Hello; Here is one notion as to how some may be protected from even new types of virus. I posted about this idea in a different web site forum last year but not on the forum. This is about exposure to similar but not the same virus. The corona virus is part of the same family as the common cold virus.

Of course this is not about how ancient human exposures would work in modern times. But the concept has been known in modern times for a long time.

Viruses: Are you susceptible to the coronavirus, flu, and more | Genetic Lifehacks


Hello; This article perhaps better explains the concept. You do not have to read very far to find the information.
When I have more time I will go thru and pull some quotes that are worth while and will edit or re post the information.

Too bad CJJon; you jumped on me a bit too soon.

The author goes out of her way to make clear she isn't talking about the current COVID-19 coronavirus. Maybe find something a bit more current that actually has some conclusions about COVID-19 and genetic immunity.

Besides, even if you show that there is some genetic mutation that protects some, it would be a rather small number of us humans who have it and it really would not make one bit of difference from a public health standpoint regards the pandemic.

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[sk47]

The author goes out of her way to make clear she isn't talking about the current COVID-19 coronavirus. Maybe find something a bit more current that actually has some conclusions about COVID-19 and genetic immunity.

Besides, even if you show that there is some genetic mutation that protects some, it would be a rather small number of us humans who have it and it really would not make one bit of difference from a public health standpoint regards the pandemic.

Hello; Here is a quote from my post. " 20,000 years is well before rapid transportation so the outbreaks likely would have been more isolated and not wide spread like today. "

Also look closer into the second link

Viruses: Are you susceptible to the coronavirus, flu, and more | Genetic Lifehacks

 

[CJJon]

Here is an interesting read...I have not found anything more current, but I didn't search too hard.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404857/

 

[CJJon]

Hello; Here is a quote from my post. " 20,000 years is well before rapid transportation so the outbreaks likely would have been more isolated and not wide spread like today. "

Also look closer into the second link

Viruses: Are you susceptible to the coronavirus, flu, and more | Genetic Lifehacks

This post makes no sense.

Not sure what your quote has to do with the FACT that any current genetic mutation that is protective rega4rding COVID-19 is trivial when looking at the pandemic from a public health standpoint.

I also read the article and posted a short conclusion that "the author goes out of her way to make clear she isn't talking about the current COVID-19 coronavirus". Looking closer isn't going to change that.

So I am not sure what point you are trying to make.

 

[Sivi70980]

Just drive the crap out of our mustangs till The Rona kills us all off right? Delta + likely to be followed by some other catchy phonetic label. People that don't think it's real or don't care will die out first and the people that are afraid of their own shadows will get the real joy of trying to survive post apocalyptic times. That's how it goes in all the movies right? At any rate, I ate bacon this morning so come at me Covid! Kidding of course!

 

[sk47]

Viruses: Are you susceptible to the coronavirus, flu, and more | Genetic Lifehacks


Hello; This article perhaps better explains the concept. You do not have to read very far to find the information.
When I have more time I will go thru and pull some quotes that are worth while and will edit or re post the information.

Too bad CJJon; you jumped on me a bit too soon.

Hello; (my comments) A few posts ago I added two links to a post. I was trying to support the notion that in the human population some individuals have protections against getting some disease caused by pathogens. This is not new information. In other outbreaks in the past some individuals when exposed to a new pathogen did not get sick. When I was first studying biology decades ago I do not recall the mechanism being known. Now there is some confidence among those in the field there is a genetic reason.

Let me say I did not intend to imply that the link I first provided had a direct connection is known to the current covid19 virus. It is too soon for that a specific genetic to be known. Odds are that some individuals will have this sort of protection is the idea. A problem is we may not be able to predict who has such protection but work is going on in the area. Perhaps someday it will be known who has such protection in good detail. I intend to go into more detail about the information in one of the links.

Viruses: Are you susceptible to the coronavirus, flu, and more | Genetic Lifehacks

Quotes from the link

“Our genome is shaped by the pathogens that our ancestors survived. This is really pretty cool – you carry specific genetic variants that were passed down to you from the ancestors who lived through diseases and epidemics.”

“All of the genetic variants that gave your ancestors a survival advantage in ages past are still written in your genome today. Pretty cool to think about!”

Hello; (my comments) These two quotes set up the idea well. As always read the link yourself. I will quote only bits of the article. There is lots more with well written comments.

“Let me give you a few examples: People who carry a sickle-cell anemia mutation are likely to have an ancestor who survived malaria.

One copy of a cystic fibrosis mutation could have protected your ancestors from dying from a cholera outbreak.

The CCR5Δ32 variant is protective against HIV / AIDS. It is theorized that it may also have protected against the black death in the Middle Ages.

About 20% of the population carries a variant that prevents them from secreting their blood type – and this also protects them from getting the norovirus and the rotavirus (aka the stomach flu).[ref] Think of this one as a superpower that you would want to have is stuck aboard a cruise ship where everyone is sick!”

Hello; (my comments); As I stated earlier these sorts of protections have been known for some time. That some individuals actually have such protection from covid19 is not known for sure. There seems to be a possibility for such. Probably because covid19 is part of a family of known virus. Details in the article.

“For viral infections, interferons are the first wave of defenders.”

“Pattern recognition receptors are also a part of the innate immune system, which is how the body recognizes foreign invaders.”

“The HLA (human leukocyte antigen) genes code for part of what is called the major histocompatibility complex (MHC). These proteins are part of the adaptive immune system and present the antigens, or pieces of the virus, on the surface of a cell. These antigens are like a flag saying ‘the virus is here!’.”

Hello; (my comments); There is a section of the article describing the body’s immune system. The above quotes are just a part. It is an interesting read.

“Genes are the blueprint for the proteins that make up the various components of the immune system. You have genes that code for the proteins that act as cellular receptors, the different pattern recognition receptors, several types of interferon, the various cytokines needed to destroy the pathogens, cell signals, and more. It’s a complicated system that keeps us resilient and able to fight off various types of pathogens, including new viruses and bacteria.”

“Genetic variants can cause slight differences in how any single part of the immune system works. Each of us is unique – able to easily fight off certain foreign invaders and slightly more susceptible to others. As a whole, this makes the human population resilient and powerful. Some people may be more susceptible to certain pathogens while others may have a mutation that protects them against that specific foreign invader.”

Hello; (my comments); The above quotes are a good summary.

“Genetic variants that influence viral susceptibility: Members: Log in to see your data file Not a member? Join now.

Hello; (my comments); My guess as I have not joined this club is you can have a genetic analysis done. A listing of some already known genetic matchups is included. I do not plan to have this sort of thing done any time soon.

“While it is too soon to know who is more susceptible to the new coronavirus strain, there are many well-studied genetic variants that impacted SARS susceptibility – as well as with other viruses.”

Hello; (my comments): My take is the new virus will be studied to see which individuals may have inherited protection from ancestors.

 

[sk47]

Here is an interesting read...I have not found anything more current, but I didn't search too hard.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404857/

Hello; I looked at the link. Before any of the rest of us make comments about it. Why don't you give us a summary yourself? Pull some quotes and break the information down for us.

 

[CJJon]

Hello; I looked at the link. Before any of the rest of us make comments about it. Why don't you give us a summary yourself? Pull some quotes and break the information down for us.

Nah. That would be a waste of my time. You and your ilk are not amenable to learning or having any sort of cogent discussion about most anything.

 

[CJJon]

Hello; (my comments) A few posts ago I added two links to a post. I was trying to support the notion that in the human population some individuals have protections against getting some disease caused by pathogens. This is not new information. In other outbreaks in the past some individuals when exposed to a new pathogen did not get sick. When I was first studying biology decades ago I do not recall the mechanism being known. Now there is some confidence among those in the field there is a genetic reason.

Let me say I did not intend to imply that the link I first provided had a direct connection is known to the current covid19 virus. It is too soon for that a specific genetic to be known. Odds are that some individuals will have this sort of protection is the idea. A problem is we may not be able to predict who has such protection but work is going on in the area. Perhaps someday it will be known who has such protection in good detail. I intend to go into more detail about the information in one of the links.

Viruses: Are you susceptible to the coronavirus, flu, and more | Genetic Lifehacks

Quotes from the link

“Our genome is shaped by the pathogens that our ancestors survived. This is really pretty cool – you carry specific genetic variants that were passed down to you from the ancestors who lived through diseases and epidemics.”

“All of the genetic variants that gave your ancestors a survival advantage in ages past are still written in your genome today. Pretty cool to think about!”

Hello; (my comments) These two quotes set up the idea well. As always read the link yourself. I will quote only bits of the article. There is lots more with well written comments.

“Let me give you a few examples: People who carry a sickle-cell anemia mutation are likely to have an ancestor who survived malaria.

One copy of a cystic fibrosis mutation could have protected your ancestors from dying from a cholera outbreak.

The CCR5Δ32 variant is protective against HIV / AIDS. It is theorized that it may also have protected against the black death in the Middle Ages.

About 20% of the population carries a variant that prevents them from secreting their blood type – and this also protects them from getting the norovirus and the rotavirus (aka the stomach flu).[ref] Think of this one as a superpower that you would want to have is stuck aboard a cruise ship where everyone is sick!”

Hello; (my comments); As I stated earlier these sorts of protections have been known for some time. That some individuals actually have such protection from covid19 is not known for sure. There seems to be a possibility for such. Probably because covid19 is part of a family of known virus. Details in the article.

“For viral infections, interferons are the first wave of defenders.”

“Pattern recognition receptors are also a part of the innate immune system, which is how the body recognizes foreign invaders.”

“The HLA (human leukocyte antigen) genes code for part of what is called the major histocompatibility complex (MHC). These proteins are part of the adaptive immune system and present the antigens, or pieces of the virus, on the surface of a cell. These antigens are like a flag saying ‘the virus is here!’.”

Hello; (my comments); There is a section of the article describing the body’s immune system. The above quotes are just a part. It is an interesting read.

“Genes are the blueprint for the proteins that make up the various components of the immune system. You have genes that code for the proteins that act as cellular receptors, the different pattern recognition receptors, several types of interferon, the various cytokines needed to destroy the pathogens, cell signals, and more. It’s a complicated system that keeps us resilient and able to fight off various types of pathogens, including new viruses and bacteria.”

“Genetic variants can cause slight differences in how any single part of the immune system works. Each of us is unique – able to easily fight off certain foreign invaders and slightly more susceptible to others. As a whole, this makes the human population resilient and powerful. Some people may be more susceptible to certain pathogens while others may have a mutation that protects them against that specific foreign invader.”

Hello; (my comments); The above quotes are a good summary.

“Genetic variants that influence viral susceptibility: Members: Log in to see your data file Not a member? Join now.

Hello; (my comments); My guess as I have not joined this club is you can have a genetic analysis done. A listing of some already known genetic matchups is included. I do not plan to have this sort of thing done any time soon.

“While it is too soon to know who is more susceptible to the new coronavirus strain, there are many well-studied genetic variants that impacted SARS susceptibility – as well as with other viruses.”

Hello; (my comments): My take is the new virus will be studied to see which individuals may have inherited protection from ancestors.

Certainly there may be an as yet to be discovered genetic mutation that prevents some small number of humans from contracting COVID-19. Big picture it is meaningless from a public health perspective. This is obviously so.

 

[sk47]

Nah. That would be a waste of my time. You and your ilk are not amenable to learning or having any sort of cogent discussion about most anything.

Hello; Some will figure you cannot summarize the article. That perhaps you just threw out a link you do not understand yourself. Such would be an irony.

 

[CJJon]

Hello; Some will figure you cannot summarize the article. That perhaps you just threw out a link you do not understand yourself. Such would be an irony.

If anything, you are a funny guy! Snort!

 

[sk47]

Certainly there may be an as yet to be discovered genetic mutation that prevents some small number of humans from contracting COVID-19. Big picture it is meaningless from a public health perspective. This is obviously so.

Hello; It does make a difference in that from the start some folks were never going to get sick by the new virus. How many would have this sort of natural immunity in the question. Since it will only be an estimate throwing out numbers would be pointless, but the numbers may be enough to make a difference by adding to herd immunity.

 

[sk47]

If anything, you are a funny guy! Snort!

Hello; I am not the one refusing to explain a link I posted. You come on here as if you are so very clever, but will not back up your own post. I suspect you have caught your self this time.
It is going to be pretty clear to the others who read this what the score is.

 

[CJJon]

Hello; It does make a difference in that from the start some folks were never going to get sick by the new virus. How many would have this sort of natural immunity in the question. Since it will only be an estimate throwing out numbers would be pointless, but the numbers may be enough to make a difference by adding to herd immunity.

This is where you are wrong. Just look at the pandemic numbers of sick and dead. Any sort of innate genetic immunity is so small as to not make much difference at all. Again, this is obviously so.

 

[wingnutt]

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