Possible Covid19 Protection

[K4fxd]

Unless you are an immunologist

Typical response. One does not need to be an immunologist to have an informed opinion

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[CJJon]

Typical response. One does not need to be an immunologist to have an informed opinion

Then express one. Your opinions are scant regarding any real information and facts. I would certainly not call them informed.

 

[K4fxd]

Ironically, I am probably one of the few on here that does,

This is the internet. I am King, because I say so.

If you understand so much why not break it down for us smucks.

 

[CJJon]

This is the internet. I am King, because I say so.

If you understand so much why not break it down for us smucks.

[The] article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus‐mediated disease. The initial sections focus on seasonal coronaviruses, SARS‐CoV, and MERS‐CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS‐CoV‐2 and COVID‐19. The article concludes by discussing research areas with current knowledge gaps and proposes several avenues for future scientific exploration in order to develop new insights into the immunology of SARS‐CoV‐2.

What specific part do you need help with? Do you need a dictionary?

 

[K4fxd]

What are the conclusions?

Instead of posting nonsense why not post ONE of the avenues for future scientific exploration

 

[CJJon]

What are the conclusions?

Instead of posting nonsense why not post ONE of the avenues for future scientific exploration

Dude, you are a cranky bastard, aren't you? Why can't you be bothered to actually read the article? Anyway, here you go...pick it apart...or ignore it. I don't really care at this point.


From a viral and host genetics point of view, there are critical knowledge gaps that direct our research agenda. Examples include the following:

• Understanding the role of ACE2, TMPRSS2, and other specific candidate host genes on COVID‐19 infection, severity, and disease outcome.
• Performing candidate gene, epigenetic, and GWAS studies across different racial and ethnic populations in order to identify genes and haplotypes associated with differential factors of infection and clinical outcome, as well as vaccine response.
• Systems genetic and biology studies to understand differential and interacting genetic effects on disease severity and outcome through the lens of the immune response network theory. 168
• Studies of any differential effect of viral mutations and recombination events on differential disease severity in the context of host comorbidities and medication usage that blocks, suppresses, or activates differential host gene expression (eg, ACE2, TMPRSS2, etc).
• Understanding SAR‐CoV‐2 viral genetics over time and geography—particularly in terms of number and frequency of viral mutations and recombination events and their relationship to viral infectivity, transmissibility, disease severity, and clinical phenotype, viral burden, disease outcome, etc.
• Understanding potential interactions between SARS‐CoV‐2 and other respiratory co‐infections (notably, between 20%‐90% of COVID‐19 patients in the United States were co‐infected with at least one other respiratory pathogen).
• Understanding interactions and functional effects of various viral point mutations and recombination events on therapeutic monoclonal antibody, antiviral, and vaccine efficacy and possible adverse events.

 

[Gregs24]

Typical response. One does not need to be an immunologist to have an informed opinion

You do if the subject is immunology!

 

[K4fxd]

You do if the subject is immunology!

With that logic I can't talk pro baseball without first being a professional baseball player.

Again socialist ideas.

 

[K4fxd]

From a viral and host genetics point of view, there are critical knowledge gaps that direct our research agenda. Examples include the following:

• Understanding the role of ACE2, TMPRSS2, and other specific candidate host genes on COVID‐19 infection, severity, and disease outcome.
• Performing candidate gene, epigenetic, and GWAS studies across different racial and ethnic populations in order to identify genes and haplotypes associated with differential factors of infection and clinical outcome, as well as vaccine response.
• Systems genetic and biology studies to understand differential and interacting genetic effects on disease severity and outcome through the lens of the immune response network theory. 168
• Studies of any differential effect of viral mutations and recombination events on differential disease severity in the context of host comorbidities and medication usage that blocks, suppresses, or activates differential host gene expression (eg, ACE2, TMPRSS2, etc).
• Understanding SAR‐CoV‐2 viral genetics over time and geography—particularly in terms of number and frequency of viral mutations and recombination events and their relationship to viral infectivity, transmissibility, disease severity, and clinical phenotype, viral burden, disease outcome, etc.
• Understanding potential interactions between SARS‐CoV‐2 and other respiratory co‐infections (notably, between 20%‐90% of COVID‐19 patients in the United States were co‐infected with at least one other respiratory pathogen).
• Understanding interactions and functional effects of various viral point mutations and recombination events on therapeutic monoclonal antibody, antiviral, and vaccine efficacy and possible adverse events.

So they are saying they don't have a clue and are doing research.

Like I said, you are posting non-sense.

 

[sk47]

Dude, you are a cranky bastard, aren't you? Why can't you be bothered to actually read the article? Anyway, here you go...pick it apart...or ignore it. I don't really care at this point.


From a viral and host genetics point of view, there are critical knowledge gaps that direct our research agenda. Examples include the following:

• Understanding the role of ACE2, TMPRSS2, and other specific candidate host genes on COVID‐19 infection, severity, and disease outcome.
• Performing candidate gene, epigenetic, and GWAS studies across different racial and ethnic populations in order to identify genes and haplotypes associated with differential factors of infection and clinical outcome, as well as vaccine response.
• Systems genetic and biology studies to understand differential and interacting genetic effects on disease severity and outcome through the lens of the immune response network theory. 168
• Studies of any differential effect of viral mutations and recombination events on differential disease severity in the context of host comorbidities and medication usage that blocks, suppresses, or activates differential host gene expression (eg, ACE2, TMPRSS2, etc).
• Understanding SAR‐CoV‐2 viral genetics over time and geography—particularly in terms of number and frequency of viral mutations and recombination events and their relationship to viral infectivity, transmissibility, disease severity, and clinical phenotype, viral burden, disease outcome, etc.
• Understanding potential interactions between SARS‐CoV‐2 and other respiratory co‐infections (notably, between 20%‐90% of COVID‐19 patients in the United States were co‐infected with at least one other respiratory pathogen).
• Understanding interactions and functional effects of various viral point mutations and recombination events on therapeutic monoclonal antibody, antiviral, and vaccine efficacy and possible adverse events.

Hello; This is just some copy and past of others comments. It shows you can copy and paste to be sure. Afraid this does not indicate understanding on your part. It is a listing of goals by the way.

 

[RPDBlueMoon]

With that logic I can't talk pro baseball without first being a professional baseball player.

Again socialist ideas.

Not really. He said that your opinion would have no value. You wouldn't have to be a professional baseball player but you could be an amateur or be connected to the sport, like being a fan or a reporter each having a different value

That's not a socialist idea at all really, quite the opposite. Socialism would mean that all of their opinions are equal regardless if you are pro, amateur, or never played because everyone is at the same level.

 

[K4fxd]

Not really. He said that your opinion would have no value. You wouldn't have to be a professional baseball player but you could be an amateur or be connected to the sport, like being a fan or a reporter.

That's not a socialist idea at all really, quite the opposite.

That went right over your head.

I can study anything and get a well enough education to have an informed opinion without getting a degree.

The socialist idea is, only experts in the field are qualified to talk about a subject.

Just another form of censorship, or as is said now, cancel culture.

 

[CJJon]

So they are saying they don't have a clue and are doing research.

Like I said, you are posting non-sense.

Yep, nonsense.

 

[CJJon]

Hello; This is just some copy and past of others comments. It shows you can copy and paste to be sure. Afraid this does not indicate understanding on your part. It is a listing of goals by the way.

What does my understanding have to do with it? I just offered it as an interesting read and you want some sort of diatribe from me about the content of the article (which is in actuality a summary itself). That really isn't how science works. It is for you to read and research and come to your own informed conclusions.

Again, you are making yourself look foolish.

 

[CJJon]

That went right over your head.

I can study anything and get a well enough education to have an informed opinion without getting a degree.

The socialist idea is, only experts in the field are qualified to talk about a subject.

Just another form of censorship, or as is said now, cancel culture.

However, your scant opinions on the matter are not informed in the least. You are quite biased as well - and that clouds your judgement.

Oh, and you don't really understand socialism.

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