Probably no real drawbacks other than cost. What about a 5.2 shortblock?
The thing about 1000hp is that's when the block distorts (depending on who you talk to) and you want the sleeves for sure.
Definitely don't want hyper pistons in a boosted engine though.
Vortech has all their installation manuals online
https://vortechsuperchargers.com/pages/ford-car-installation-manuals
The manuals list all the parts included.
The biggest differences are going to be:
Supercharger bracket
Fuel system parts
All of the supercharger piping
Possibly the...
It's going to depend on your combo. Plus you need a way to measure so you can make changes and see what's faster. And you need consistency from good tires. Otherwise you're just guessing.